The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway

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<jats:p>In this study, we demonstrated that miR-640 is significantly downregulated in breast cancer (BC) tissues and cell lines. Overexpression of miR-640 inhibited the proliferation and migration of BC <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic>, while depletion of miR-640 exhibited the opposite effect. Importantly, miR-640 could directly target Wnt7b, thereby regulating Wnt/β-catenin signaling pathway in BC. In conclusion, miR-640/Wnt7b suppresses BC cells tumorigenesis <jats:italic>via</jats:italic> Wnt/β-catenin signaling pathway, which might be novel targets for BC targeted therapy.</jats:p>

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