Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantation. The IgE allotype is an important marker of graft-versus-host disease.

DOI PDF PubMed 被引用文献1件
  • C Ushiyama
    Division of Rheumatology, Juntendo University, School of Medicine , Tokyo ,
  • T Hirano
    Division of Hematology, Department of Internal Medicine, Juntendo University, School of Medicine , Tokyo ,
  • H Miyajima
    Division of Pathobiology, Juntendo University, School of Medicine , Tokyo ,
  • K Okumura
    Department of Immunology, Juntendo University, School of Medicine , Tokyo ,
  • Z Ovary
    Department of Pathology, New York University Medical School and Kaplan Comprehensive Cancer Center , New York, NY 10016
  • H Hashimoto
    Division of Rheumatology, Juntendo University, School of Medicine , Tokyo ,

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公開日
1995-03
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.4049/jimmunol.154.6.2687
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>Induction of a graft-vs-host reaction in irradiated (BALB/c X C57BL/6)F1 mice (CBF1 mice) with bone marrow cells (BMC) plus spleen cells of BALB/c mice leads to bone marrow transplantation--GVHD (BMT-GVHD). BMT-GVHD is characterized by liver disease, splenomegaly, and hypergammopathy. In addition, we found that increased serum IgE and IgG1 levels were correlated with BMT-GVHD such as liver disease and splenomegaly. The allotype of increased IgE levels in BMT-GVHD was IgEa of donor origin, not IgEb of host origin. We also found that in the thymus of murine BMT-GVHD, the CD4+ CD8+ double-positive T cells were decreased, but the CD4+ CD8- or CD4- CD8+ single-positive T cells were increased. Interestingly, double-positive T cells appeared in the spleen, suggesting that abnormal T cell differentiation existed in murine BMT-GVHD. When the recipients were treated with anti-IL-4 Ab (11B11), the increase of IgE and IgG1 was markedly reduced and liver disease and splenomegaly were also prevented. Moreover, abnormal T cell differentiation and maturation were suppressed. These observations suggest that IL-4 plays an important role in immunoregulation or pathogenesis of allogeneic effects, and 11B11 prevents immunodysfunction including T cell differentiation in the thymus or the spleen and autoimmune symptoms in murine BMT-GVHD.</jats:p>

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