Highlights of neuroanatomical discoveries of the mammalian gonadotropin‐releasing hormone system
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- Rebecca E. Campbell
- Centre for Neuroendocrinology and Department of Physiology, School of Biomedical Sciences University of Otago Dunedin New Zealand
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- Lique M. Coolen
- Department of Biological Sciences Kent State University Kent Ohio USA
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- Gloria E. Hoffman
- Department of Biology Morgan State University Baltimore Maryland USA
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- Erik Hrabovszky
- Laboratory of Reproductive Neurobiology Institute of Experimental Medicine Budapest Hungary
抄録
<jats:title>Abstract</jats:title><jats:p>The anatomy and morphology of gonadotropin‐releasing hormone (GnRH) neurons makes them both a joy and a challenge to investigate. They are a highly unique population of neurons given their developmental migration into the brain from the olfactory placode, their relatively small number, their largely scattered distribution within the rostral forebrain, and, in some species, their highly varied individual anatomical characteristics. These unique features have posed technological hurdles to overcome and promoted fertile ground for the establishment and use of creative approaches. Historical and more contemporary discoveries defining GnRH neuron anatomy remain critical in shaping and challenging our views of GnRH neuron function in the regulation of reproductive function. We begin this review with a historical overview of anatomical discoveries and developing methodologies that have shaped our understanding of the reproductive axis. We then highlight significant discoveries across specific groups of mammalian species to address some of the important comparative aspects of GnRH neuroanatomy. Lastly, we touch on unresolved questions and opportunities for future neuroanatomical research on this fascinating and important population of neurons.</jats:p>
収録刊行物
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- Journal of Neuroendocrinology
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Journal of Neuroendocrinology 34 (5), 2022-05
Wiley