Serum inflammatory marker levels in serous macular detachment secondary to diabetic macular edema

<jats:sec><jats:title>Purpose</jats:title><jats:p> To evaluate the serum inflammatory marker levels in serous macular detachment (SMD) secondary to diabetic macular edema (DME). </jats:p></jats:sec><jats:sec><jats:title>Material and Methods</jats:title><jats:p> Patients with DME were divided into two groups according to the presence of SMD. Group 1 consisted of 40 patients with SMD, Group 2 consisted of 40 patients without SMD, and Group 3 consisted of 40 healthy subjects. Neutrophil and mean platelet volume (MPV) were obtained from blood samples. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the systemic immune inflammation index (SII) were calculated. In Group 1 and 2 sub-group analysis was done according to grade of diabetic retinopathy (DR) and the results were analyzed in these subgroups. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> The neutrophils, MPV, NLR, and SII levels were significantly higher in Group 1 ( p = 0.000, p = 0.004, p = 0.000, p = 0.001, respectively). In subgroup analysis; the neutrophils, NLR, and SII levels were significantly higher in patients with proliferative DR ( p = 0.044, p = 0.046, p = 0.046, respectively) and the SII levels were significantly higher in patients with severe nonproliferative DR in Group 1 ( p = 0.039). The mean CMT values were 548.8 ± 138.3 µm in Group 1 and 420.1 ± 112.7 µm in Group 2. The CMT values were significantly higher in Group 1 ( p: 0.000). However, there was no significant correlation between the CMT values and the systemic inflamatuar markers levels ( p>0.05) in both of the groups. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> NLR and SII levels were significantly higher in DME with SMD, especially in advanced cases. Elevated serum inflammatory markers might be associated with a higher incidence of SMD. </jats:p></jats:sec>