HLA-VBSeq v2: improved HLA calling accuracy with full-length Japanese class-I panel
抄録
<jats:title>Abstract</jats:title><jats:p>HLA-VBSeq is an HLA calling tool developed to infer the most likely HLA types from high-throughput sequencing data. However, there is still room for improvement in specific genetic groups because of the diversity of HLA alleles in human populations. Here, we present HLA-VBSeq v2, a software application that makes use of a new Japanese HLA reference panel to enhance calling accuracy for Japanese HLA class-I genes. Our analysis showed significant improvements in calling accuracy in all HLA regions, with prediction accuracies achieving over 99.0, 97.8, and 99.8% in HLA-A, B and C, respectively.</jats:p>
収録刊行物
-
- Human Genome Variation
-
Human Genome Variation 6 (1), 29-, 2019-06-19
Springer Science and Business Media LLC