Structural and functional insights into the unique CBS–CP12 fusion protein family in cyanobacteria

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  • Claudia Hackenberg
    European Molecular Biology Laboratory (EMBL), Deutsches Elektronen-Synchrotron (DESY), 22607 Hamburg, Germany;
  • Johanna Hakanpää
    European Molecular Biology Laboratory (EMBL), Deutsches Elektronen-Synchrotron (DESY), 22607 Hamburg, Germany;
  • Fei Cai
    Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;
  • Svetlana Antonyuk
    Institute of Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZX, United Kingdom;
  • Caroline Eigner
    European Molecular Biology Laboratory (EMBL), Deutsches Elektronen-Synchrotron (DESY), 22607 Hamburg, Germany;
  • Sven Meissner
    Department of Microbiology, Institute for Biochemistry and Biology, University of Potsdam, 14476 Potsdam-Golm, Germany;
  • Mikko Laitaoja
    Department of Chemistry, University of Eastern Finland, FI-80101 Joensuu, Finland;
  • Janne Jänis
    Department of Chemistry, University of Eastern Finland, FI-80101 Joensuu, Finland;
  • Cheryl A. Kerfeld
    Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;
  • Elke Dittmann
    Department of Microbiology, Institute for Biochemistry and Biology, University of Potsdam, 14476 Potsdam-Golm, Germany;
  • Victor S. Lamzin
    European Molecular Biology Laboratory (EMBL), Deutsches Elektronen-Synchrotron (DESY), 22607 Hamburg, Germany;

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<jats:title>Significance</jats:title> <jats:p>Carbon fixation is arguably one of the most important metabolic processes on Earth. Stand-alone CP12 proteins are major players in the regulation of this pathway in all oxygenic photosynthetic organisms, yet their intrinsic disorder has so far hampered the capturing of a principal part of their structure. Here we provide structural insights into CP12 by investigating an uncharacterized CP12 fusion protein, CBS–CP12, which is widespread among cyanobacteria, and reveal a unique hexameric structure. Our data further extend the existing knowledge of the regulation of photosynthesis and carbon fixation by the CP12 protein family, suggesting a more versatile role of this protein family in global redox regulation, predominantly in bloom-forming cyanobacteria that pose major threats in lakes and reservoirs.</jats:p>

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