The Mechanism of Antibody-Induced Stimulation and Inhibition of the Immune Response

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<jats:title>Abstract</jats:title> <jats:p>The influence of passively administered specific IgG and IgM antibodies on the immune response of mice to sheep erythrocytes is described. The stimulation of the immune response to a given dose of antigen by partially purified IgM is proportional to the square root of the concentration of antibody injected. Labeling experiments show that this stimulation is caused by an enhanced concentration of antigen in the spleen. Low doses of IgG produce the same effects, namely antigen concentration in the spleen and stimulation of the number of plaque-forming cells. But in contrast to IgM, high doses of IgG do not concentrate the antigen in the spleen and severely inhibit the immune response. It is therefore suggested that antibody may have two effects: IgM and low doses of IgG stimulate an immune response by concentrating the antigen, whereas high doses of antibody inhibit by coating the antigen or by competing with the antigen receptor sites.</jats:p>

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