Remote electronic effect on the N-heterocyclic carbene-catalyzed asymmetric intramolecular Stetter reaction and structural revision of products
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- Tsubasa Inokuma
- Graduate School of Pharmaceutical Sciences, Tokushima University, Shomachi, Tokushima 770-8505, Japan
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- Kohei Iritani
- Graduate School of Pharmaceutical Sciences, Tokushima University, Shomachi, Tokushima 770-8505, Japan
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- Yuki Takahara
- Graduate School of Pharmaceutical Sciences, Tokushima University, Shomachi, Tokushima 770-8505, Japan
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- Chunzhao Sun
- Graduate School of Pharmaceutical Sciences, Tokushima University, Shomachi, Tokushima 770-8505, Japan
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- Yousuke Yamaoka
- Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
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- Satoru Kuwano
- Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
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- Ken-ichi Yamada
- Graduate School of Pharmaceutical Sciences, Tokushima University, Shomachi, Tokushima 770-8505, Japan
Description
<jats:p>The remote electron-withdrawing substituents on the chiral N-heterocyclic carbene enhanced rate and enantioselectivity in the asymmetric intramolecular Stetter reaction. The absolute configurations of the products were revised by X-ray diffraction.</jats:p>
Journal
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- Chemical Communications
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Chemical Communications 59 (36), 5375-5378, 2023
Royal Society of Chemistry (RSC)