A Convergent Synthesis of Tetracyclic Indole Compounds by a Palladium-Catalyzed Cross-Coupling and Tandem Cyclization Reaction
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- Toshio Nishikawa
- Graduate School of Bioagricultural Sciences, Nagoya University
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- Yoshiki Ono
- Graduate School of Bioagricultural Sciences, Nagoya University
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- Keiko Higuchi
- Graduate School of Bioagricultural Sciences, Nagoya University
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- Masashi Yamaguchi
- Graduate School of Bioagricultural Sciences, Nagoya University
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- Kumi Sugino
- Graduate School of Bioagricultural Sciences, Nagoya University
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- Atsuo Nakazaki
- Department of Chemistry and Biological Sciences, Iwate University
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- Masaatsu Adachi
- Graduate School of Pharmaceutical Sciences, Tohoku University
説明
<jats:title>Abstract</jats:title><jats:p>A new strategy for the convergent synthesis of the ABCD ring system of indole terpene alkaloids has been developed based on a Sonogashira coupling of an o-iodoaniline (the A ring) with an alkyne bearing the D ring. After a tandem palladium-catalyzed cyclization, the tetracyclic ABCD ring structure found in the terpene indole alkaloids was obtained in good yield.</jats:p>
収録刊行物
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- Synlett
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Synlett 34 (04), 364-368, 2022-12-19
Georg Thieme Verlag KG
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360861704780262016
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- ISSN
- 14372096
- 09365214
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- データソース種別
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- Crossref
- KAKEN