Therapeutic effects of KCC2 chloride transporter activation on detrusor overactivity in mice with spinal cord injury

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  • Kyohei Watanabe
    Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu, Japan
  • Masaru Ishibashi
    Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu, Japan
  • Takahisa Suzuki
    Department of Urology, Kanagawa Rehabilitation Hospital, Atsugi, Japan
  • Atsushi Otsuka
    Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan
  • Naoki Yoshimura
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Hideaki Miyake
    Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan
  • Atsuo Fukuda
    Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu, Japan

Abstract

<jats:p> This study is the first report to suggest that activation of the Cl<jats:sup>−</jats:sup> transporter K<jats:sup>+</jats:sup>-Cl<jats:sup>−</jats:sup> cotransporter 2 may be a therapeutic modality for the treatment of spinal cord injury-induced detrusor overactivity by targeting bladder efferent pathways. </jats:p>

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