抄録
<jats:p><jats:italic>Babesia</jats:italic> are tick-borne protozoan parasites that can infect livestock, pets, wildlife animals, and humans. In the mammalian host, they invade and multiply within red blood cells (RBCs). To support their development as obligate intracellular parasites, <jats:italic>Babesia</jats:italic> export numerous proteins to modify the RBC during invasion and development. Such exported proteins are likely important for parasite survival and pathogenicity and thus represent candidate drug or vaccine targets. The availability of complete genome sequences and the establishment of transfection systems for several <jats:italic>Babesia</jats:italic> species have aided the identification and functional characterization of exported proteins. Here, we review exported <jats:italic>Babesia</jats:italic> proteins; discuss their functions in the context of immune evasion, cytoadhesion, and nutrient uptake; and highlight possible future topics for research and application in this field.</jats:p>
収録刊行物
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- PLOS Pathogens
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PLOS Pathogens 18 (9), e1010770-, 2022-09-15
Public Library of Science (PLoS)