Role of adropin in arterial stiffening associated with obesity and type 2 diabetes

DOI Web Site 参考文献75件
  • Thomas J. Jurrissen
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
  • Francisco I. Ramirez-Perez
    Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri
  • Francisco J. Cabral-Amador
    Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri
  • Rogerio N. Soares
    Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri
  • Ryan J. Pettit-Mee
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
  • Edgar E. Betancourt-Cortes
    Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri
  • Neil J. McMillan
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
  • Neekun Sharma
    Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri
  • Helena N. M. Rocha
    Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri
  • Shumpei Fujie
    Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri
  • Mariana Morales-Quinones
    Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri
  • Yoskaly Lazo-Fernandez
    Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri
  • Andrew A. Butler
    Department of Pharmacology and Physiological Sciences, Saint Louis University, Saint Louis, Missouri
  • Subhashis Banerjee
    Department of Pharmacology and Physiological Sciences, Saint Louis University, Saint Louis, Missouri
  • Harold S. Sacks
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California
  • Jamal A. Ibdah
    Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri
  • Elizabeth J. Parks
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
  • R. Scott Rector
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
  • Camila Manrique-Acevedo
    Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri
  • Luis A. Martinez-Lemus
    Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri
  • Jaume Padilla
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri

抄録

<jats:p> Arterial stiffening, a characteristic feature of obesity and type 2 diabetes (T2D), contributes to the development and progression of cardiovascular diseases. Herein we establish that adropin is decreased in obese and T2D models and furthermore provide evidence that reduced adropin may directly contribute to arterial stiffening. Collectively, findings from this work support the notion that “hypoadropinemia” should be considered as a putative target for the prevention and treatment of arterial stiffening in obesity and T2D. </jats:p>

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