“Out‐of‐the‐box” Granular Gel Bath Based on Cationic Polyvinyl Alcohol Microgels for Embedded Extrusion Printing

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  • Jinfeng Zeng
    Department of Applied Chemistry Graduate School of Engineering Osaka University 2‐1 Yamadaoka Suita Osaka 565‐0871 Japan
  • Zhengtian Xie
    Department of Applied Chemistry Graduate School of Engineering Osaka University 2‐1 Yamadaoka Suita Osaka 565‐0871 Japan
  • Yasumasa Dekishima
    Mitsubishi Chemical Corporation Science and Innovation Center 1000 Kamoshida‐cho, Aoba‐ku Yokohama Kanagawa 227‐8502 Japan
  • Setsuka Kuwagaki
    Mitsubishi Chemical Corporation Osaka R&D Center 13‐1 Muroyama 2‐chome Ibaraki Osaka 567‐0052 Japan
  • Norihito Sakai
    Mitsubishi Chemical Corporation Osaka R&D Center 13‐1 Muroyama 2‐chome Ibaraki Osaka 567‐0052 Japan
  • Michiya Matsusaki
    Department of Applied Chemistry Graduate School of Engineering Osaka University 2‐1 Yamadaoka Suita Osaka 565‐0871 Japan

抄録

<jats:title>Abstract</jats:title><jats:p>Embedded extrusion printing provides a versatile platform for fabricating complex hydrogel‐based biological structures with living cells. However, the time‐consuming process and rigorous storage conditions of current support baths hinder their commercial application. This work reports a novel “out‐of‐the‐box” granular support bath based on chemically crosslinked cationic polyvinyl alcohol (PVA) microgels, which is ready to use by simply dispersing the lyophilized bath in water. Notably, with ionic modification, PVA microgels yield reduced particle size, uniform distribution, and appropriate rheological properties, contributing to high‐resolution printing. Following by the lyophilization and re‐dispersion process, ion‐modified PVA baths recover to its original state, with unchanged particle size, rheological properties, and printing resolution, demonstrating its stability and recoverability. Lyophilization facilitates the long‐term storage and delivery of granular gel baths, and enables the application of “out‐of‐the‐box” support materials, which will greatly simplify experimental procedures, avoid labor‐intensive and time‐consuming operations, thus accelerating the broad commercial development of embedded bioprinting.</jats:p>

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