Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders

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  • Junichi Yamamoto
    School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan
  • Takumi Ito
    Institute of Medical Science, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan
  • Yuki Yamaguchi
    School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan
  • Hiroshi Handa
    Center for Future Medical Research, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan

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<jats:p>Thalidomide and its derivatives are the only protein degraders currently used in clinical practice. This tutorial review provides an overview of the mechanism of action of thalidomide-based degraders and their future perspectives.</jats:p>

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