Effect of SARS-CoV-2 BNT162b2 mRNA vaccine on thyroid autoimmunity: A twelve-month follow-up study
説明
<jats:sec><jats:title>Objectives</jats:title><jats:p>Graves’ disease (GD) has been highlighted as a possible adverse effect of the respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine. However, it is unknown if the SARS-CoV-2 vaccine disrupts thyroid autoimmunity. We aimed to present long-term follow-up of thyroid autoimmunity after the SARS-CoV-2 BNT162b2 mRNA vaccine.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Serum samples collected from seventy Japanese healthcare workers at baseline, 32 weeks after the second dose (pre-third dose), and 4 weeks after the third dose of the vaccine were analyzed. The time courses of anti-SARS-CoV-2 spike immunoglobulin G (IgG) antibody, thyroid-stimulating hormone receptor antibody (TRAb), and thyroid function were evaluated. Anti-thyroglobulin antibodies (TgAb) and anti-thyroid peroxidase antibodies (TPOAb) were additionally evaluated in thirty-three participants.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The median age was 50 (IQR, 38-54) years and 69% were female. The median anti-spike IgG antibody titer was 17627 (IQR, 10898-24175) U/mL 4 weeks after the third dose. The mean TRAb was significantly increased from 0.81 (SD, 0.05) IU/L at baseline to 0.97 (SD, 0.30) IU/L 4 weeks after the third dose without functional changes. An increase in TRAb was positively associated with female sex (β = 0.32, <jats:italic>P</jats:italic> = 0.008) and low basal FT4 (β = -0.29, <jats:italic>P</jats:italic> = 0.02) and FT3 (β = -0.33, <jats:italic>P</jats:italic> = 0.004). TgAb was increased by the third dose. Increase in TgAb was associated with history of the thyroid diseases (β = 0.55, <jats:italic>P <</jats:italic>0.001).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>SARS-CoV-2 BNT162b2 mRNA vaccine can disrupt thyroid autoimmunity. Clinicians should consider the possibility that the SARS-CoV-2 vaccine may disrupt thyroid autoimmunity.</jats:p></jats:sec>
収録刊行物
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- Frontiers in Endocrinology
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Frontiers in Endocrinology 14 2023-01-27
Frontiers Media SA
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キーワード
- Male
- BNT162b2 vaccine
- COVID-19 Vaccines
- SARS-CoV-2
- COVID-19
- Thyrotropin
- Autoimmunity
- Middle Aged
- RC648-665
- Antibodies, Viral
- Diseases of the endocrine glands. Clinical endocrinology
- Graves Disease
- Endocrinology
- thyroid autoimmunity
- Humans
- Female
- mRNA Vaccines
- Graves’ disease
- thyroid-stimulating hormone receptor antibody
- BNT162 Vaccine
- Follow-Up Studies
詳細情報 詳細情報について
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- CRID
- 1360861707379905920
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- ISSN
- 16642392
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- PubMed
- 37554767
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE