Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement

DOI Web Site 参考文献34件 オープンアクセス
  • Kumiko Yoshihara
    National Institute of Advanced Industrial Science and Technology (AIST), Health and Medical Research Institute, 2217-14 Hayashi-cho, Takamatsu 761-0395, Kagawa, Japan
  • Noriyuki Nagaoka
    Advanced Research Center for Oral and Craniofacial Science, Okayama University Dental School, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Okayama, Japan
  • Yoji Makita
    National Institute of Advanced Industrial Science and Technology (AIST), Health and Medical Research Institute, 2217-14 Hayashi-cho, Takamatsu 761-0395, Kagawa, Japan
  • Yasuhiro Yoshida
    Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo 060-8586, Hokkaido, Japan
  • Bart Van Meerbeek
    Department of Oral Health Sciences, BIOMAT & UZ Leuven (University Hospitals Leuven), Dentistry, KU Leuven (University of Leuven), Kapucijnenvoer 7, 3000 Leuven, Belgium

抄録

<jats:p>Despite being able to adhesively restore teeth, adhesives and cement do not possess any anticariogenic protection potential, by which caries recurrence may still occur and reduce the clinical lifetime of adhesive restorations. Several antibacterial agents have been incorporated into dental adhesives and cement to render them anticariogenic. Due to an additional therapeutic effect, such materials are classified as ‘dental combination products’ with more strict market regulations. We incorporated cetylpyridinium chloride (CPC), often used for oral hygiene applications, into montmorillonite (CPC-Mont), the latter to serve as a carrier for controlled CPC release. CPC-Mont incorporated into tissue conditioner has been approved by the Pharmaceuticals and Medical Devices Agency (PmontMDA) in Japan. To produce a clinically effective dental cement with the antibacterial potential to prevent secondary caries, we incorporated CPC-Mont into PMMA resin cement. We measured the flexural strength, shear bond strength onto dentin, CPC release, and the biofilm-inhibition potential of the experimental CPC-Mont-containing PMMA cement. An 8 and 10 wt% CPC-Mont concentration revealed the antibacterial potential without reducing the mechanical properties of the PMMA cement.</jats:p>

収録刊行物

参考文献 (34)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ