Increased frequency of clindamycin‐resistant <i>Cutibacterium acnes</i> strains isolated from Japanese patients with acne vulgaris caused by the prevalence of exogenous resistance genes

DOI Web Site Web Site 参考文献24件 オープンアクセス
  • Sahya Koyanagi
    Department of Clinical Microbiology, School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan
  • Juri Koizumi
    Department of Clinical Microbiology, School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan
  • Keisuke Nakase
    Department of Clinical Microbiology, School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan
  • Nobukazu Hayashi
    Department of Dermatology Toranomon Hospital Tokyo Japan
  • Yuki Horiuchi
    Akihabara Skin Clinic Tokyo Japan
  • Kaoru Watanabe
    Watanabe Dermatological Clinic Nagoya Japan
  • Toshiya Asai
    Asai Dermatology Clinic Yokohama Japan
  • Akiko Yamazaki
    Yamazaki Skin Clinic Kyoto Japan
  • Emi Nakazaki
    Emi Skin Clinic Tokyo Japan
  • Hidemasa Nakaminami
    Department of Clinical Microbiology, School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan

抄録

<jats:title>Abstract</jats:title><jats:p><jats:italic>Cutibacterium acnes</jats:italic>, a resident bacterium of the skin, is a target for antimicrobial treatment of acne vulgaris, because it exacerbates inflammation. Recently, antimicrobial‐resistant <jats:italic>C. acnes</jats:italic> strains have been isolated worldwide, and their prevalence has led to failure of antimicrobial treatment. This study aimed to analyze the antimicrobial resistance of <jats:italic>C. acnes</jats:italic> strains isolated from Japanese patients with acne vulgaris who visited the hospital and dermatological clinics between 2019 and 2020. Resistance rates to roxithromycin and clindamycin increased during 2019 to 2020 compared with those during 2013 to 2018. Additionally, the proportion of doxycycline‐resistant and low‐susceptibility strains (minimum inhibitory concentration [MIC] ≥8 μg/mL) increased. No difference in clindamycin resistance rates between patients with and without a history of antimicrobial use was observed during 2019 to 2020, which were significantly higher for patients with a history than for patients without a history during 2016 to 2018. The proportion of high‐level clindamycin‐resistant strains (MIC ≥256 μg/mL) gradually increased; particularly, the resistance rate was 2.5 times higher in 2020 than that in 2013. The proportion of strains showing high‐level clindamycin resistance that also have the exogenous resistance genes <jats:italic>erm</jats:italic>(X) or <jats:italic>erm</jats:italic>(50), which confer high resistance, showed a strong positive correlation (<jats:italic>r</jats:italic> = 0.82). Strains with the multidrug resistance plasmid pTZC1 encoding <jats:italic>erm</jats:italic>(50) and <jats:italic>tet</jats:italic>(W) genes were frequent in clinic patients. Notably, most strains with <jats:italic>erm</jats:italic>(X) or <jats:italic>erm</jats:italic>(50) were classified as single‐locus sequence types A and F (traditional types IA1 and IA2). Our data show that the prevalence of antimicrobial‐resistant <jats:italic>C. acnes</jats:italic> is increasing in patients with acne vulgaris attributable to acquisition of exogenous genes in specific strains. To control the increasing prevalence of antimicrobial‐resistant strains, it is important to select the appropriate antimicrobials while taking into consideration the latest information on resistant strains.</jats:p>

収録刊行物

参考文献 (24)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ