Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC
Description
<jats:p>We investigated the genetic predisposition for the pathogenesis of Stevens–Johnson syndrome/epidermal necrolysis with severe ocular complications (SJS/TEN with SOC). Cold medicines (CMs) including multi-ingredient cold-medications and non-steroidal anti-inflammatory drugs (NSAIDs) were implicated in the development of SJS/TEN with SOC. Studies on the association between HLA genotypes and CM-related SJS/TEN with SOC (CM-SJS/TEN with SOC) revealed an association with <jats:italic>HLA-A*02:06</jats:italic> in the Japanese; it may be a marker in Koreans. <jats:italic>HLA-B*44:03</jats:italic> was associated with the Japanese, Thais, and Indians; in Brazilians of European ancestry, it may be a positive marker. <jats:italic>PTGER3</jats:italic> is a susceptibility gene; <jats:italic>HLA-A*02:06</jats:italic> and <jats:italic>PTGER3</jats:italic> polymorphisms exerted additive effects in Japanese and Korean patients. A genome-wide association study showed that <jats:italic>IKZF1</jats:italic> was associated with the Japanese. A meta-analysis including Japanese, Koreans, Indians, and Brazilians also revealed an association between CM-SJS/TEN with SOC and <jats:italic>IKZF1.</jats:italic> The upregulation of hsa-miR-628-3p in the plasma of SJS/TEN with SOC patients may suppress the expression of <jats:italic>TLR3</jats:italic> and innate immune-related genes. Not only CMs but also the interaction of <jats:italic>TLR3</jats:italic>, <jats:italic>PTGER3</jats:italic>, <jats:italic>IKZF1</jats:italic>, and <jats:italic>HLA</jats:italic> and maybe some microbial infections are necessary for the onset of SJS/TEN with SOC.</jats:p>
Journal
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- Frontiers in Genetics
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Frontiers in Genetics 13 912478-, 2022-07-11
Frontiers Media SA
