Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction

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  • E. Motori
    Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
  • I. Atanassov
    Proteomics Core Facility, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
  • S. M. V. Kochan
    Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany.
  • K. Folz-Donahue
    FACS & Imaging Core Facility, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
  • V. Sakthivelu
    Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany.
  • P. Giavalisco
    Metabolomics Core Facility, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
  • N. Toni
    Center for Psychiatric Neurosciences, Department of Psychiatry, Lausanne University Hospital, Lausanne University, Lausanne, Switzerland.
  • J. Puyal
    Department of Fundamental Neurosciences, University of Lausanne, 1005 Lausanne, Switzerland.
  • N.-G. Larsson
    Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.

Abstract

<jats:p>Proteomic analysis of dysfunctional neurons reveals a metabolic program that is activated to counteract neurodegeneration.</jats:p>

Journal

  • Science Advances

    Science Advances 6 (35), eaba8271-, 2020-08-28

    American Association for the Advancement of Science (AAAS)

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