Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction
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- E. Motori
- Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
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- I. Atanassov
- Proteomics Core Facility, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
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- S. M. V. Kochan
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany.
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- K. Folz-Donahue
- FACS & Imaging Core Facility, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
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- V. Sakthivelu
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany.
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- P. Giavalisco
- Metabolomics Core Facility, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
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- N. Toni
- Center for Psychiatric Neurosciences, Department of Psychiatry, Lausanne University Hospital, Lausanne University, Lausanne, Switzerland.
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- J. Puyal
- Department of Fundamental Neurosciences, University of Lausanne, 1005 Lausanne, Switzerland.
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- N.-G. Larsson
- Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
Abstract
<jats:p>Proteomic analysis of dysfunctional neurons reveals a metabolic program that is activated to counteract neurodegeneration.</jats:p>
Journal
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- Science Advances
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Science Advances 6 (35), eaba8271-, 2020-08-28
American Association for the Advancement of Science (AAAS)
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Details 詳細情報について
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- CRID
- 1360861709546467840
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- ISSN
- 23752548
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- Data Source
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- Crossref