-
- Mitsuhiro Yoneda
- Department of Biochemistry, Nagasaki University School of Medicine , Nagasaki 852-8523, Japan
-
- Takeya Nakagawa
- Department of Biochemistry, Nagasaki University School of Medicine , Nagasaki 852-8523, Japan
-
- Naoko Hattori
- Department of Biochemistry, Nagasaki University School of Medicine , Nagasaki 852-8523, Japan
-
- Takashi Ito
- Department of Biochemistry, Nagasaki University School of Medicine , Nagasaki 852-8523, Japan
抄録
<jats:title>Abstract</jats:title> <jats:p>The nucleolus is a membrane-less organelle sequestered from the nucleus by liquid droplet formation through a liquid–liquid phase separation (LLPS). It plays important roles in cell homoeostasis through its internal thermodynamic changes. Reversible nucleolar transitions between coalescence and dispersion are dependent on the concentrations, conformations and interactions of its molecular liquid droplet-forming components, including DNA, RNA and protein. The liquid droplet-like properties of the nucleolus enable its diverse dynamic roles. The liquid droplet formation mechanism, by which the nucleolus is sequestered from the nucleoplasm despite the absence of a membrane, explains a number of complex nucleolar functions.</jats:p>
収録刊行物
-
- The Journal of Biochemistry
-
The Journal of Biochemistry 170 (2), 153-162, 2021-08-01
Oxford University Press (OUP)