A dummy-run evaluation of postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trials for cervical cancer
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- Won Kyung Cho
- Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
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- Heejung Kim
- Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
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- Won Park
- Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
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- Sang-Won Kim
- Department of Radiation Oncology, Konyang University College of Medicine, Daejeon, Republic of Korea
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- Jongwon Kim
- Department of Radiation Oncology, Konyang University College of Medicine, Daejeon, Republic of Korea
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- Kang Kyu Lee
- Department of Radiation Oncology, Wonkwang University School of Medicine, Iksan, Republic of Korea
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- Jeong Geun Oh
- Department of Radiation Oncology, Wonkwang University School of Medicine, Iksan, Republic of Korea
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- Mee Sun Yoon
- Department of Radiation Oncology, Chonnam National University Medical School, Gwangju, Republic of Korea
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- Ju-Young Song
- Department of Radiation Oncology, Chonnam National University Medical School, Gwangju, Republic of Korea
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- Ki Jung Ahn
- Department of Radiation Oncology, Inje University Busan Paik Hospital, Busan, Republic of Korea
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- Sung Kwang Park
- Department of Radiation Oncology, Inje University Busan Paik Hospital, Busan, Republic of Korea
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- Jin Hwa Choi
- Department of Radiation Oncology, Chung-Ang University Hospital, Seoul, South Korea
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- Jino Bak
- Department of Radiation Oncology, Chung-Ang University Hospital, Seoul, South Korea
Abstract
<jats:title>Abstract</jats:title> <jats:p>The postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trial is a phase II study to evaluate toxicity following hypofractionated intensity modulated radiation therapy (IMRT) for cervical cancer. This study describes the results of a benchmark procedure for RT quality assurance of the POHIM-RT trial. Six participating institutions were provided computed tomography for RT planning and an IMRT plan for a sample and were instructed to delineate volumes, create a treatment plan and quality assurance (QA) plan, and submit the results of all procedures. The inter-institutional agreements on RT volume and plan results were evaluated using the kappa value and dice similarity coefficients. The simultaneous truth and performance level estimation (STAPLE) method was employed to generate a consensus target volume. The treatment volumes, organs-at-risk volumes, and results of the RT plan and QA reported by the institutions were acceptable and adhered well to the protocol. In terms of clinical target volume (CTV) delineation, there were differences between the institutions, particularly in vaginal cuff and paracolpium subsites. Consensus CTV was generated from the collected CTVs with the STAPLE method. The participating institutions showed considerable agreement regarding volume, dose and QA results. To improve CTV agreement in CTV, we provided feedback with images of the consensus target volume and detailed written guidelines for specific subsites that were the most heterogeneous.</jats:p>
Journal
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- Journal of Radiation Research
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Journal of Radiation Research 62 (1), 149-154, 2020-10-14
Oxford University Press (OUP)
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Details 詳細情報について
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- CRID
- 1360861710430362624
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- ISSN
- 13499157
- 04493060
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- Data Source
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- Crossref