An atlas of the protein-coding genes in the human, pig, and mouse brain
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- Evelina Sjöstedt
- Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
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- Wen Zhong
- Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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- Linn Fagerberg
- Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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- Max Karlsson
- Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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- Nicholas Mitsios
- Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
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- Csaba Adori
- Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
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- Per Oksvold
- Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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- Fredrik Edfors
- Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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- Agnieszka Limiszewska
- Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
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- Feria Hikmet
- Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
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- Jinrong Huang
- Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.
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- Yutao Du
- BGI-Shenzhen, Shenzhen 518083, China.
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- Lin Lin
- Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.
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- Zhanying Dong
- Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.
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- Ling Yang
- Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.
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- Xin Liu
- BGI-Shenzhen, Shenzhen 518083, China.
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- Hui Jiang
- MGI, BGI-Shenzhen, Shenzhen 518083, China.
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- Xun Xu
- BGI-Shenzhen, Shenzhen 518083, China.
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- Jian Wang
- BGI-Shenzhen, Shenzhen 518083, China.
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- Huanming Yang
- BGI-Shenzhen, Shenzhen 518083, China.
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- Lars Bolund
- Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.
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- Adil Mardinoglu
- Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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- Cheng Zhang
- Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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- Kalle von Feilitzen
- Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
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- Cecilia Lindskog
- Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
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- Fredrik Pontén
- Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
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- Yonglun Luo
- Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.
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- Tomas Hökfelt
- Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
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- Mathias Uhlén
- Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
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- Jan Mulder
- Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
説明
<jats:title>Mapping the mammalian brain</jats:title> <jats:p> The diverse physiology of the brain is reflected in its complex organization at regional, cellular, and subcellular levels. Sjöstedt <jats:italic>et al.</jats:italic> combined data—both newly acquired and from other large-scale brain mapping projects—from transcriptomics, single-cell genomics, in situ hybridization, and antibody-based protein profiling to map the molecular profiles in human, pig, and mouse brain. The analysis is consistent with a conserved basic brain architecture during mammalian evolution, but it does show differences in regional gene expression profiles. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay5947">eaay5947</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 367 (6482), aay5947-, 2020-03-06
American Association for the Advancement of Science (AAAS)
