A Heat-Killed <i>Cryptococcus</i> Mutant Strain Induces Host Protection against Multiple Invasive Mycoses in a Murine Vaccine Model

DOI Web Site 被引用文献1件
  • Yina Wang
    Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
  • Keyi Wang
    Graduate School of Biomedical Sciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
  • Jorge A. Masso-Silva
    Graduate School of Biomedical Sciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
  • Amariliz Rivera
    Graduate School of Biomedical Sciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
  • Chaoyang Xue
    Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
  • Stuart M. Levitz
    editor
  • Tamara L. Doering
    editor

抄録

<jats:p> Invasive fungal infections kill more than 1.5 million people each year, with limited treatment options. There is no vaccine available in clinical use to prevent and control fungal infections. Our recent studies showed that a mutant of the F-box protein Fbp1, a subunit of the SCF(Fbp1) E3 ligase in <jats:named-content content-type="genus-species">Cryptococcus neoformans</jats:named-content> , elicited superior protective Th1 host immunity. Here, we demonstrate that the heat-killed <jats:italic>fbp1</jats:italic> Δ cells (HK-fbp1) can be harnessed to confer protection against a challenge by the virulent parental strain, even in animals depleted of CD4 <jats:sup>+</jats:sup> T cells. This finding is particularly important in the context of HIV/AIDS-induced immune deficiency. Moreover, we observed that HK-fbp1 vaccination induces significant cross-protection against challenge with diverse invasive fungal pathogens. Thus, our data suggest that HK-fbp1 has the potential to be a broad-spectrum vaccine candidate against invasive fungal infections in both immunocompetent and immunocompromised populations. </jats:p>

収録刊行物

  • mBio

    mBio 10 (6), 2019-12-24

    American Society for Microbiology

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