Sequential replay of nonspatial task states in the human hippocampus

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  • Nicolas W. Schuck
    Max Planck Research Group NeuroCode, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany.
  • Yael Niv
    Princeton Neuroscience Institute and Department of Psychology, Princeton University, Washington Road, Princeton, NJ 08544, USA.

Description

<jats:title>Replay of activity in the human brain</jats:title> <jats:p>Electrophysiological recordings in rats and mice have shown that specific hippocampal neuronal activity patterns are sequentially reactivated during rest periods or sleep. Does the human hippocampus also replay activity sequences, even in a nonspatial task, such as, for example, decision-making? Schuck and Niv studied functional magnetic resonance imaging signals in subjects after they had learned a decision-making task. While people rested, the replay of activity patterns in the hippocampus reflected the order of previous task-state sequences. Thus, sequential hippocampal reactivation might participate in decision-making in humans.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw5181">eaaw5181</jats:related-article> </jats:p>

Journal

  • Science

    Science 364 (6447), 2019-06-28

    American Association for the Advancement of Science (AAAS)

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