Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: The Hamburg City Health Study COVID programme
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- Elina Larissa Petersen
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Alina Goßling
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Gerhard Adam
- University Medical Center Hamburg-Eppendorf Department of Diagnostic and Interventional Radiology and Nuclear Medicine, , Hamburg, Germany
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- Martin Aepfelbacher
- University Medical Center Hamburg-Eppendorf Institute of Medical Microbiology, Virology and Hygiene, , Hamburg, Germany
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- Christian-Alexander Behrendt
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Ersin Cavus
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Bastian Cheng
- University Medical Center Hamburg-Eppendorf Department of Neurology, , Hamburg, Germany
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- Nicole Fischer
- University Medical Center Hamburg-Eppendorf Institute of Medical Microbiology, Virology and Hygiene, , Hamburg, Germany
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- Jürgen Gallinat
- University Clinic Hamburg-Eppendorf Clinic and Policlinic for Psychiatry and Psychotherapy, , Hamburg, Germany
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- Simone Kühn
- University Clinic Hamburg-Eppendorf Clinic and Policlinic for Psychiatry and Psychotherapy, , Hamburg, Germany
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- Christian Gerloff
- University Medical Center Hamburg-Eppendorf Department of Neurology, , Hamburg, Germany
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- Uwe Koch-Gromus
- University Medical Center Hamburg-Eppendorf (UKE) Department of Medical Psychology, , Hamburg, Germany
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- Martin Härter
- University Medical Center Hamburg-Eppendorf (UKE) Department of Medical Psychology, , Hamburg, Germany
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- Uta Hanning
- University Medical Center Hamburg-Eppendorf Department of Diagnostic and Interventional Radiology and Nuclear Medicine, , Hamburg, Germany
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- Tobias B. Huber
- University Medical Center Hamburg-Eppendorf III. Department of Medicine, , Hamburg, Germany
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- Stefan Kluge
- University Medical Center Hamburg-Eppendorf Department of Intensive Care Medicine, , Hamburg, Germany
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- Johannes K. Knobloch
- University Medical Center Hamburg-Eppendorf Institute of Medical Microbiology, Virology and Hygiene, , Hamburg, Germany
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- Piotr Kuta
- University Medical Center Hamburg- Eppendorf Institute of Clinical Chemistry and Laboratory Medicine, , Hamburg, Germany
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- Christian Schmidt-Lauber
- University Medical Center Hamburg-Eppendorf III. Department of Medicine, , Hamburg, Germany
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- Marc Lütgehetmann
- University Medical Center Hamburg-Eppendorf Institute of Medical Microbiology, Virology and Hygiene, , Hamburg, Germany
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- Christina Magnussen
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Carola Mayer
- University Medical Center Hamburg-Eppendorf Department of Neurology, , Hamburg, Germany
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- Kai Muellerleile
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Julia Münch
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Felix Leonard Nägele
- University Medical Center Hamburg-Eppendorf Department of Neurology, , Hamburg, Germany
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- Marvin Petersen
- University Medical Center Hamburg-Eppendorf Department of Neurology, , Hamburg, Germany
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- Thomas Renné
- University Medical Center Hamburg- Eppendorf Institute of Clinical Chemistry and Laboratory Medicine, , Hamburg, Germany
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- Katharina Alina Riedl
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- David Leander Rimmele
- University Medical Center Hamburg-Eppendorf Department of Neurology, , Hamburg, Germany
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- Ines Schäfer
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Holger Schulz
- University Medical Center Hamburg-Eppendorf (UKE) Department of Medical Psychology, , Hamburg, Germany
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- Enver Tahir
- University Medical Center Hamburg-Eppendorf Department of Diagnostic and Interventional Radiology and Nuclear Medicine, , Hamburg, Germany
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- Benjamin Waschki
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Jan-Per Wenzel
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Tanja Zeller
- German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Luebeck , Hamburg, Germany
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- Andreas Ziegler
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Götz Thomalla
- University Medical Center Hamburg-Eppendorf Department of Neurology, , Hamburg, Germany
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- Raphael Twerenbold
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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- Stefan Blankenberg
- University Heart and Vascular Center Department of Cardiology, , Hamburg, Germany
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<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Aims</jats:title> <jats:p>Long-term sequelae may occur after SARS-CoV-2 infection. We comprehensively assessed organ-specific functions in individuals after mild to moderate SARS-CoV-2 infection compared with controls from the general population.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and results</jats:title> <jats:p>Four hundred and forty-three mainly non-hospitalized individuals were examined in median 9.6 months after the first positive SARS-CoV-2 test and matched for age, sex, and education with 1328 controls from a population-based German cohort. We assessed pulmonary, cardiac, vascular, renal, and neurological status, as well as patient-related outcomes. Bodyplethysmography documented mildly lower total lung volume (regression coefficient −3.24, adjusted P = 0.014) and higher specific airway resistance (regression coefficient 8.11, adjusted P = 0.001) after SARS-CoV-2 infection. Cardiac assessment revealed slightly lower measures of left (regression coefficient for left ventricular ejection fraction on transthoracic echocardiography −0.93, adjusted P = 0.015) and right ventricular function and higher concentrations of cardiac biomarkers (factor 1.14 for high-sensitivity troponin, 1.41 for N-terminal pro-B-type natriuretic peptide, adjusted P ≤ 0.01) in post-SARS-CoV-2 patients compared with matched controls, but no significant differences in cardiac magnetic resonance imaging findings. Sonographically non-compressible femoral veins, suggesting deep vein thrombosis, were substantially more frequent after SARS-CoV-2 infection (odds ratio 2.68, adjusted P < 0.001). Glomerular filtration rate (regression coefficient −2.35, adjusted P = 0.019) was lower in post-SARS-CoV-2 cases. Relative brain volume, prevalence of cerebral microbleeds, and infarct residuals were similar, while the mean cortical thickness was higher in post-SARS-CoV-2 cases. Cognitive function was not impaired. Similarly, patient-related outcomes did not differ.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Subjects who apparently recovered from mild to moderate SARS-CoV-2 infection show signs of subclinical multi-organ affection related to pulmonary, cardiac, thrombotic, and renal function without signs of structural brain damage, neurocognitive, or quality-of-life impairment. Respective screening may guide further patient management.</jats:p> </jats:sec>
収録刊行物
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- European Heart Journal
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European Heart Journal 43 (11), 1124-1137, 2022-01-06
Oxford University Press (OUP)