Guidelines for in vivo mouse models of myocardial infarction

DOI Web Site 2 Citations
  • Merry L. Lindsey
    Department of Cellular and Integrative Physiology, Center for Heart and Vascular Research, University of Nebraska Medical Center, Omaha, Nebraska
  • Keith R. Brunt
    Department of Pharmacology, Faculty of Medicine, Dalhousie University, Saint John, New Brunswick, Canada
  • Jonathan A. Kirk
    Department of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Chicago, Illinois
  • Petra Kleinbongard
    Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany
  • John W. Calvert
    Carlyle Fraser Heart Center of Emory University Hospital Midtown, Atlanta, Georgia
  • Lisandra E. de Castro Brás
    Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, North Carolina
  • Kristine Y. DeLeon-Pennell
    Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina
  • Dominic P. Del Re
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey
  • Nikolaos G. Frangogiannis
    Division of Cardiology, Department of Medicine, The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York
  • Stefan Frantz
    Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany
  • Richard J. Gumina
    Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio
  • Ganesh V. Halade
    Division of Cardiovascular Sciences, Department of Medicine, University of South Florida, Tampa, Florida
  • Steven P. Jones
    Department of Medicine, Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky
  • Rebecca H. Ritchie
    Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Victoria, Australia
  • Francis G. Spinale
    Cardiovascular Translational Research Center, University of South Carolina School of Medicine and the Columbia Veteran Affairs Medical Center, Columbia, South Carolina
  • Edward B. Thorp
    Department of Pathology and Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
  • Crystal M. Ripplinger
    Department of Pharmacology, University of California Davis School of Medicine, Davis, California
  • Zamaneh Kassiri
    Department of Physiology, Cardiovascular Research Center, University of Alberta, Edmonton, Alberta, Canada

Abstract

<jats:p> Despite significant improvements in reperfusion strategies, acute coronary syndromes all too often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to remodeling of the left ventricle (LV), the development of LV dysfunction, and ultimately progression to heart failure (HF). Accordingly, an improved understanding of the underlying mechanisms of MI remodeling and progression to HF is necessary. One common approach to examine MI pathology is with murine models that recapitulate components of the clinical context of acute coronary syndrome and subsequent MI. We evaluated the different approaches used to produce MI in mouse models and identified opportunities to consolidate methods, recognizing that reperfused and nonreperfused MI yield different responses. The overall goal in compiling this consensus statement is to unify best practices regarding mouse MI models to improve interpretation and allow comparative examination across studies and laboratories. These guidelines will help to establish rigor and reproducibility and provide increased potential for clinical translation. </jats:p><jats:p> Listen to another corresponding podcast at https://ajpheart.podbean.com/e/guidelines-for-in-vivo-mouse-models-of-myocardial-infarction/ . </jats:p>

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