Type IV Pili of Streptococcus sanguinis Contribute to Pathogenesis in Experimental Infective Endocarditis
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- Anthony M. Martini
- Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
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- Bridget S. Moricz
- Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
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- Laurel J. Woods
- Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
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- Bradley D. Jones
- Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
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- Christopher N. LaRock
- editor
抄録
<jats:p> This work provides evidence that type IV pili produced by <jats:named-content content-type="genus-species">Streptococcus sanguinis</jats:named-content> SK36 are critical to the ability of these bacteria to attach to and colonize the aortic heart valve (endocarditis). We found that an <jats:named-content content-type="genus-species">S. sanguinis</jats:named-content> type IV pili mutant strain was defective in causing platelet-dependent aggregation in a 24-h infection assay but not in a 1-h platelet aggregation assay, suggesting that the type IV pili act at later stages of vegetation development. </jats:p>
収録刊行物
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- Microbiology Spectrum
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Microbiology Spectrum 9 (3), 2021-12-22
American Society for Microbiology