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- Allison L Soung
- Center for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine , St. Louis, MO , USA
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- Abigail Vanderheiden
- Center for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine , St. Louis, MO , USA
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- Anna S Nordvig
- Division of Neurodegenerative Diseases, Department of Neurology, Weill Cornell Medicine , New York, NY , USA
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- Cheick A Sissoko
- Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute , New York, NY , USA
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- Peter Canoll
- Department of Pathology and Cell Biology, Columbia University , New York, NY , USA
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- Madeline B Mariani
- Department of Psychiatry, Columbia University , New York, NY , USA
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- Xiaoping Jiang
- Center for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine , St. Louis, MO , USA
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- Traci Bricker
- Department of Medicine, Washington University School of Medicine , St. Louis, MO , USA
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- Gorazd B Rosoklija
- Department of Pathology and Cell Biology, Columbia University , New York, NY , USA
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- Victoria Arango
- Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute , New York, NY , USA
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- Mark Underwood
- Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute , New York, NY , USA
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- J John Mann
- Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute , New York, NY , USA
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- Andrew J Dwork
- Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute , New York, NY , USA
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- James E Goldman
- Department of Pathology and Cell Biology, Columbia University , New York, NY , USA
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- Adrianus C M Boon
- Department of Medicine, Washington University School of Medicine , St. Louis, MO , USA
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- Maura Boldrini
- Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute , New York, NY , USA
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- Robyn S Klein
- Center for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine , St. Louis, MO , USA
説明
<jats:title>Abstract</jats:title> <jats:p>Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with acute and postacute cognitive and neuropsychiatric symptoms including impaired memory, concentration, attention, sleep and affect. Mechanisms underlying these brain symptoms remain understudied. Here we report that SARS-CoV-2-infected hamsters exhibit a lack of viral neuroinvasion despite aberrant blood–brain barrier permeability. Hamsters and patients deceased from coronavirus disease 2019 (COVID-19) also exhibit microglial activation and expression of interleukin (IL)-1β and IL-6, especially within the hippocampus and the medulla oblongata, when compared with non-COVID control hamsters and humans who died from other infections, cardiovascular disease, uraemia or trauma. In the hippocampal dentate gyrus of both COVID-19 hamsters and humans, we observed fewer neuroblasts and immature neurons. Protracted inflammation, blood–brain barrier disruption and microglia activation may result in altered neurotransmission, neurogenesis and neuronal damage, explaining neuropsychiatric presentations of COVID-19. The involvement of the hippocampus may explain learning, memory and executive dysfunctions in COVID-19 patients.</jats:p>
収録刊行物
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- Brain
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Brain 145 (12), 4193-4201, 2022-08-25
Oxford University Press (OUP)