Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment
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- Elisa Guma
- Computational Brain Anatomy Laboratory, Cerebral Imaging Center, Douglas Mental Health University Institute, Montreal, QC H4H 1R3, Canada
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- Maude Bordeleau
- Integrated Program in Neuroscience, McGill University, Montreal, QC H3A 0G4, Canada
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- Fernando González Ibáñez
- Axe Neurosciences, Centre de Recherche du Centre Hospitalier Universitaire de Québec–Université Laval, Quebec City, QC G1V 4G2, Canada
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- Katherine Picard
- Axe Neurosciences, Centre de Recherche du Centre Hospitalier Universitaire de Québec–Université Laval, Quebec City, QC G1V 4G2, Canada
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- Emily Snook
- Computational Brain Anatomy Laboratory, Cerebral Imaging Center, Douglas Mental Health University Institute, Montreal, QC H4H 1R3, Canada
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- Gabriel Desrosiers-Grégoire
- Computational Brain Anatomy Laboratory, Cerebral Imaging Center, Douglas Mental Health University Institute, Montreal, QC H4H 1R3, Canada
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- Shoshana Spring
- Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
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- Jason P. Lerch
- Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
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- Brian J. Nieman
- Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
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- Gabriel A. Devenyi
- Computational Brain Anatomy Laboratory, Cerebral Imaging Center, Douglas Mental Health University Institute, Montreal, QC H4H 1R3, Canada
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- Marie-Eve Tremblay
- Axe Neurosciences, Centre de Recherche du Centre Hospitalier Universitaire de Québec–Université Laval, Quebec City, QC G1V 4G2, Canada
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- M. Mallar Chakravarty
- Computational Brain Anatomy Laboratory, Cerebral Imaging Center, Douglas Mental Health University Institute, Montreal, QC H4H 1R3, Canada
説明
<jats:title>Significance</jats:title><jats:p>Prenatal exposure to maternal infection increases the risk of developing mental health disorders, such as schizophrenia and autism spectrum disorder. Exposure to maternal immune activation has been associated with a number of neuroanatomical deficits in adolescent and adult offspring, with differing effects based on the gestational timing of infection. However, little is known about how the embryo brain is affected. We show, using whole-brain MRI, that maternal immune activation significantly affects brain anatomy. When the exposure occurs early in pregnancy, volume reductions are mainly observed, while the opposite is true for exposure later in pregnancy. Furthermore, we identify alterations to the density of certain classes of neurons and glia, which have been associated with stress and inflammation in the brain.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 119 (12), e2114545119-, 2022-03-14
Proceedings of the National Academy of Sciences