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- Dijoia B. Darden
- Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA
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- Lauren S. Kelly
- Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA
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- Brittany P. Fenner
- Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA
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- Lyle L. Moldawer
- Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA
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- Alicia M. Mohr
- Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA
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- Philip A. Efron
- Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA
説明
<jats:p>Implementation of protocolized surveillance, diagnosis, and management of septic patients, and of surgical sepsis patients in particular, is shown to result in significantly increased numbers of patients surviving their initial hospitalization. Currently, most surgical sepsis patients will rapidly recover from sepsis; however, many patients will not rapidly recover, but instead will go on to develop chronic critical illness (CCI) and experience dismal long-term outcomes. The elderly and comorbid patient is highly susceptible to death or CCI after sepsis. Here, we review aspects of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) endotype to explain the underlying pathobiology of a dysregulated immune system in sepsis survivors who develop CCI; then, we explore targets for immunomodulatory therapy.</jats:p>
収録刊行物
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- Journal of Clinical Medicine
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Journal of Clinical Medicine 10 (8), 1742-, 2021-04-17
MDPI AG