Secreted pectin monooxygenases drive plant infection by pathogenic oomycetes

  • Federico Sabbadin
    Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK.
  • Saioa Urresti
    Department of Chemistry, University of York, York YO10 5DD, UK.
  • Bernard Henrissat
    Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257 CNRS, Université Aix-Marseille, 163 Avenue de Luminy, 13288 Marseille, France.
  • Anna O. Avrova
    Cell and Molecular Sciences, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.
  • Lydia R. J. Welsh
    Cell and Molecular Sciences, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.
  • Peter J. Lindley
    Department of Chemistry, University of York, York YO10 5DD, UK.
  • Michael Csukai
    Syngenta, Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK.
  • Julie N. Squires
    Cell and Molecular Sciences, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.
  • Paul H. Walton
    Department of Chemistry, University of York, York YO10 5DD, UK.
  • Gideon J. Davies
    Department of Chemistry, University of York, York YO10 5DD, UK.
  • Neil C. Bruce
    Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK.
  • Stephen C. Whisson
    Cell and Molecular Sciences, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.
  • Simon J. McQueen-Mason
    Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK.

抄録

<jats:title> Potato pectin falls to <jats:italic>Phytophthora</jats:italic> </jats:title> <jats:p> <jats:italic>Phytophthora infestans</jats:italic> is a plant oomycete pathogen that drove the potato famines of the 1800s and continues to afflict potato fields today. The polysaccharide pectin makes up about a third of the cell wall in potatoes. Sabbadin <jats:italic>et al</jats:italic> . identified a family of lytic polysaccharide monooxygenases (LMPOs) that cleave pectin and are upregulated in <jats:italic>P. infestans</jats:italic> during infection. Silencing the relevant LMPO gene successfully inhibited <jats:italic>P. infestans</jats:italic> infections. These findings open doors for disease intervention targets and for biotech applications. —PJH </jats:p>

収録刊行物

  • Science

    Science 373 (6556), 774-779, 2021-08-13

    American Association for the Advancement of Science (AAAS)

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