Secreted pectin monooxygenases drive plant infection by pathogenic oomycetes
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- Federico Sabbadin
- Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK.
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- Saioa Urresti
- Department of Chemistry, University of York, York YO10 5DD, UK.
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- Bernard Henrissat
- Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257 CNRS, Université Aix-Marseille, 163 Avenue de Luminy, 13288 Marseille, France.
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- Anna O. Avrova
- Cell and Molecular Sciences, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.
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- Lydia R. J. Welsh
- Cell and Molecular Sciences, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.
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- Peter J. Lindley
- Department of Chemistry, University of York, York YO10 5DD, UK.
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- Michael Csukai
- Syngenta, Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK.
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- Julie N. Squires
- Cell and Molecular Sciences, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.
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- Paul H. Walton
- Department of Chemistry, University of York, York YO10 5DD, UK.
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- Gideon J. Davies
- Department of Chemistry, University of York, York YO10 5DD, UK.
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- Neil C. Bruce
- Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK.
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- Stephen C. Whisson
- Cell and Molecular Sciences, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.
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- Simon J. McQueen-Mason
- Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK.
抄録
<jats:title> Potato pectin falls to <jats:italic>Phytophthora</jats:italic> </jats:title> <jats:p> <jats:italic>Phytophthora infestans</jats:italic> is a plant oomycete pathogen that drove the potato famines of the 1800s and continues to afflict potato fields today. The polysaccharide pectin makes up about a third of the cell wall in potatoes. Sabbadin <jats:italic>et al</jats:italic> . identified a family of lytic polysaccharide monooxygenases (LMPOs) that cleave pectin and are upregulated in <jats:italic>P. infestans</jats:italic> during infection. Silencing the relevant LMPO gene successfully inhibited <jats:italic>P. infestans</jats:italic> infections. These findings open doors for disease intervention targets and for biotech applications. —PJH </jats:p>
収録刊行物
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- Science
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Science 373 (6556), 774-779, 2021-08-13
American Association for the Advancement of Science (AAAS)