The inflammatory markers of multisystem inflammatory syndrome in children (MIS‐C) and adolescents associated with COVID‐19: A meta‐analysis
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- Yan Zhao
- Department of Pediatrics People's Hospital of Chongqing Banan District Chongqing China
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- Lijuan Yin
- Department of Respiratory Medicine Children's Hospital of Chongqing Medical University Chongqing China
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- Jenil Patel
- Department of Epidemiology The University of Texas Health Science Center at Houston (UTHealth) School of Public Health Dallas Texas USA
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- Lei Tang
- Department of Pediatrics People's Hospital of Chongqing Banan District Chongqing China
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- Ying Huang
- Department of Respiratory Medicine Children's Hospital of Chongqing Medical University Chongqing China
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>To conduct a systematic review and meta‐analysis to characterize inflammatory markers in comparisons of multisystem inflammatory syndrome in children (MIS‐C) versus severe/non‐severe COVID‐19, severe MIS‐C versus non‐severe MIS‐C, and among age groups of MIS‐C. Nine databases were searched for studies on inflammatory markers of MIS‐C. After quality checks, data were pooled using a fixed or random effects model. Inflammatory markers included white blood cell count (WBC) or leukocytes, absolute lymphocyte count (ALC), absolute neutrophil count (ANC), platelet count (PLT), C‐reactive protein (CRP), procalcitonin (PCT), ferritin, D‐dimer, lactate dehydrogenase (LDH), fibrinogen, and erythrocyte sedimentation rate (ESR) for comparisons by severity and age. Twenty‐one studies with 1735 participants yielded 787 MIS‐C patients. Compared to non‐severe COVID‐19 patients, MIS‐C patients had lower ALC and higher ANC, CRP, and D‐dimer levels. Compared to severe COVID‐19 patients, MIS‐C patients had lower LDH and PLT counts and higher ESR levels. Severe MIS‐C patients had higher levels of WBC, ANC, CRP, D‐dimer, and ferritin than non‐severe MIS‐C patients. For MIS‐C, younger children (0–5 years) had lower CRP and ferritin levels than middle‐aged/older children/adolescents. Measurement of inflammatory markers might assist clinicians in accurate evaluation and diagnosis of MIS‐C and the associated disorders.</jats:p></jats:sec>
Journal
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- Journal of Medical Virology
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Journal of Medical Virology 93 (7), 4358-4369, 2021-04
Wiley
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Details 詳細情報について
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- CRID
- 1360861711990674176
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- ISSN
- 10969071
- 01466615
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- Data Source
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- Crossref