An <i>Alphavirus</i> -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates
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- Jesse H. Erasmus
- Department of Microbiology, University of Washington, Seattle, WA 98109, USA.
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- Amit P. Khandhar
- HDT Bio, Seattle, WA 98102, USA.
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- Megan A. O’Connor
- Department of Microbiology, University of Washington, Seattle, WA 98109, USA.
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- Alexandra C. Walls
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Emily A. Hemann
- Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.
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- Patience Murapa
- Department of Microbiology, University of Washington, Seattle, WA 98109, USA.
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- Jacob Archer
- Department of Microbiology, University of Washington, Seattle, WA 98109, USA.
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- Shanna Leventhal
- Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
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- James T. Fuller
- Department of Microbiology, University of Washington, Seattle, WA 98109, USA.
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- Thomas B. Lewis
- Department of Microbiology, University of Washington, Seattle, WA 98109, USA.
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- Kevin E. Draves
- Department of Microbiology, University of Washington, Seattle, WA 98109, USA.
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- Samantha Randall
- Department of Microbiology, University of Washington, Seattle, WA 98109, USA.
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- Kathryn A. Guerriero
- Washington National Primate Research Center, Seattle, WA 98121, USA.
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- Malcolm S. Duthie
- HDT Bio, Seattle, WA 98102, USA.
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- Darrick Carter
- HDT Bio, Seattle, WA 98102, USA.
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- Steven G. Reed
- HDT Bio, Seattle, WA 98102, USA.
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- David W. Hawman
- Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
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- Heinz Feldmann
- Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
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- Michael Gale
- Washington National Primate Research Center, Seattle, WA 98121, USA.
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- David Veesler
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Peter Berglund
- HDT Bio, Seattle, WA 98102, USA.
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- Deborah Heydenburg Fuller
- Department of Microbiology, University of Washington, Seattle, WA 98109, USA.
説明
<jats:p>Replicating RNA vaccine delivered by lipid inorganic nanoparticles induces neutralizing antibody and T cells against SARS-CoV-2 in mice and macaques.</jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 12 (555), 9396-, 2020-08-05
American Association for the Advancement of Science (AAAS)