Metalloproteinases and their roles in human cancer

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  • Roopali Roy
    The Vascular Biology Program, Boston Children's Hospital and the Department of Surgery Boston Children's Hospital and Harvard Medical School Boston Massachusetts
  • Golnaz Morad
    The Vascular Biology Program, Boston Children's Hospital and the Department of Surgery Boston Children's Hospital and Harvard Medical School Boston Massachusetts
  • Andrej Jedinak
    The Vascular Biology Program, Boston Children's Hospital and the Department of Surgery Boston Children's Hospital and Harvard Medical School Boston Massachusetts
  • Marsha A. Moses
    The Vascular Biology Program, Boston Children's Hospital and the Department of Surgery Boston Children's Hospital and Harvard Medical School Boston Massachusetts

説明

<jats:title>ABSTRACT</jats:title><jats:p>It is now widely appreciated that members of the matrix metalloproteinase (MMP) family of enzymes play a key role in cancer development and progression along with many of the hallmarks associated with them. The activity of these enzymes has been directly implicated in extracellular matrix remodeling, the processing of growth factors and receptors, the modulation of cell migration, proliferation, and invasion, the epithelial to mesenchymal transition, the regulation of immune responses, and the control of angiogenesis. Certain MMP family members have been validated as biomarkers of a variety of human cancers including those of the breast, brain, pancreas, prostate, ovary, and others. The related metalloproteinases, the A disintegrin and metalloproteinases (ADAMs), share a number of these functions as well. Here, we explore these essential metalloproteinases and some of their disease‐associated activities in detail as well as some of their complementary translational potential. Anat Rec, 2019. © 2019 Wiley Periodicals, Inc.</jats:p>

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