The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer
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- J. A. Stephenson
- Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
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- O. Al-Taan
- Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
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- A. Arshad
- Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
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- B. Morgan
- Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK
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- M. S. Metcalfe
- Department of Surgery, University Hospitals of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK
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- A. R. Dennison
- Department of Surgery, University Hospitals of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK
説明
<jats:p>Omega-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid, and docosahexaenoic acid have been shown to have multiple beneficial antitumour actions that affect the essential alterations that dictate malignant growth. In this review we explore the putative mechanisms of action of omega-3 polyunsaturated fatty acid in cancer protection in relation to self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion, and how these will hopefully translate from bench to bedside.</jats:p>
収録刊行物
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- Journal of Lipids
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Journal of Lipids 2013 1-13, 2013
Hindawi Limited
