Facile difluoromethylation of aliphatic alcohols with an <i>S</i>-(difluoro-methyl)sulfonium salt: reaction, scope and mechanistic study
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- Guo-Kai Liu
- School of Pharmaceutical Sciences
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- Xin Li
- School of Pharmaceutical Sciences
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- Wen-Bing Qin
- School of Pharmaceutical Sciences
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- Xiao-Shui Peng
- Department of Chemistry
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- Henry N. C. Wong
- Department of Chemistry
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- Linxing Zhang
- Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics
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- Xinhao Zhang
- Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics
説明
<p>Facile difluoromethylation of alcohols is herein described, and the mechanistic study reveals that the difluorocarbene pathway is rational <italic>via</italic> a five-membered transition state with the participation of water.</p>
収録刊行物
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- Chemical Communications
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Chemical Communications 55 (52), 7446-7449, 2019
Royal Society of Chemistry (RSC)