Meta-Analysis and Structural Dynamics of the Emergence of Genetic Variants of SARS-CoV-2

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<jats:title>Graphical Abstract</jats:title><jats:p>Errors are regularly made when SARS-CoV-2 replicates its RNA genome. The viral polymerase complex is error-prone with imperfect proofreading abilities. These errors or mutations often lead to deleterious or neutral effects on the virus. However, sometimes these mutations have a positive effect and create genetic variants of the virus with different features including increased transmissibility, pathogenicity, and immune escape capabilities. When mutations work collaboratively to create a new virus feature, this is called epistasis.</jats:p><jats:p />

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