説明
<jats:title>Abstract</jats:title><jats:p>Resting-state EEG microstates are brief (50–100 ms) periods, in which the spatial configuration of scalp global field power remains quasi-stable before rapidly shifting to another configuration. Changes in microstate parameters have been described in patients with psychotic disorders. These changes have also been observed in individuals with a clinical or genetic high risk, suggesting potential usefulness of EEG microstates as a biomarker for psychotic disorders. The present study aimed to investigate the potential of EEG microstates as biomarkers for psychotic disorders and future transition to psychosis in patients at ultra-high-risk (UHR). We used 19-channel clinical EEG recordings and orthogonal contrasts to compare temporal parameters of four normative microstate classes (A–D) between patients with first-episode psychosis (FEP; <jats:italic>n</jats:italic> = 29), UHR patients with (UHR-T; <jats:italic>n</jats:italic> = 20) and without (UHR-NT; <jats:italic>n</jats:italic> = 34) later transition to psychosis, and healthy controls (HC; <jats:italic>n</jats:italic> = 25). Microstate A was increased in patients (FEP & UHR-T & UHR-NT) compared to HC, suggesting an unspecific state biomarker of general psychopathology. Microstate B displayed a decrease in FEP compared to both UHR patient groups, and thus may represent a state biomarker specific to psychotic illness progression. Microstate D was significantly decreased in UHR-T compared to UHR-NT, suggesting its potential as a selective biomarker of future transition in UHR patients.</jats:p>
収録刊行物
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- Translational Psychiatry
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Translational Psychiatry 10 (1), 2020-08-24
Springer Science and Business Media LLC