Maternal Diet Is Associated with Human Milk Oligosaccharide Profile

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  • Marta Selma‐Royo
    Institute of Agrochemistry and Food Technology‐National Research Council (IATA‐CSIC) Paterna Valencia 46980 Spain
  • Sonia González
    Department of Functional Biology University of Oviedo Oviedo Asturias 33006 Spain
  • Miguel Gueimonde
    Diet Microbiota, and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA) Oviedo Asturias 33011 Spain
  • Melinda Chang
    Department of Pediatrics University of California San Diego La Jolla CA 92093 USA
  • Annalee Fürst
    Department of Pediatrics University of California San Diego La Jolla CA 92093 USA
  • Cecilia Martínez‐Costa
    Department of Pediatrics, School of Medicine University of Valencia Valencia 46010 Spain
  • Lars Bode
    Department of Pediatrics University of California San Diego La Jolla CA 92093 USA
  • Maria Carmen Collado
    Institute of Agrochemistry and Food Technology‐National Research Council (IATA‐CSIC) Paterna Valencia 46980 Spain

説明

<jats:sec><jats:title>Scope</jats:title><jats:p>Human milk oligosaccharides (HMOs) are complex glycans that are abundant in human milk. The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown. Thus, this study is aimed to examine the association between maternal diet and HMO profiles.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>This is a cross‐sectional study of the MAMI cohort with 101 human milk samples from healthy mothers. HMO profiling is assessed by quantitative HPLC. Maternal dietary information is recorded through an FFQ, and perinatal factors including the mode of delivery, antibiotic exposure, and breastfeeding practices, are collected. A more significant effect of diet on HMO profiles is observed in secretor mothers than in non‐secretor mothers. (Poly)phenols and fibers, both soluble and insoluble, and several insoluble polysaccharides, pectin, and MUFA are associated with the secretor HMO profiles.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Maternal diet is associated with the composition and diversity of HMO in a secretor status‐dependent manner. The relationship between maternal diet and bioactive compounds, including HMOs, which are present in human milk, needs further research due its potential impact on infant development and health outcomes.</jats:p></jats:sec>

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