Cardiac MRI–derived Extracellular Volume Fraction versus Myocardium-to-Lumen R1 Ratio at Postcontrast T1 Mapping for Detecting Cardiac Amyloidosis

DOI Web Site PubMed 35 References
  • Masafumi Kidoh
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Seitaro Oda
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Seiji Takashio
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Yawara Kawano
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Hidetaka Hayashi
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Kosuke Morita
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Takafumi Emoto
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Shinsuke Shigematsu
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Fumihiro Yoshimura
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Takeshi Nakaura
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Yasunori Nagayama
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Masao Matsuoka
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Mitsuharu Ueda
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Kenichi Tsujita
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
  • Toshinori Hirai
    From the Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).

Description

To evaluate the diagnostic performance of myocardium-to-lumen R1 (1/T1) ratio on postcontrast T1 maps for the detection of cardiac amyloidosis in a large patient sample.This retrospective study included consecutive patients who underwent MRI-derived extracellular volume fraction (MRI ECV) analysis between March 2017 and July 2021 because of known or suspected heart failure or cardiomyopathy. Pre- and postcontrast T1 maps were generated using the modified Look-Locker inversion recovery sequence. Diagnostic performances of MRI ECV and myocardium-to-lumen R1 ratio on postcontrast T1 maps (a simplified index not requiring a native T1 map and hematocrit level data) for detecting cardiac amyloidosis were evaluated using the area under the receiver operating characteristic curve (AUC), sensitivity, and specificity.Of 352 patients (mean age, 63 years ± 16 [SD]; 235 men), 136 had cardiac amyloidosis. MRI ECV showed 89.0% (121 of 136; 95% CI: 82%, 94%) sensitivity and 98.6% (213 of 216; 95% CI: 96%, 100%) specificity for helping detect cardiac amyloidosis (cutoff value of 40% [AUC, 0.99 {95% CI: 0.97, 1.00};Postcontrast myocardium-to-lumen R1 ratio showed excellent diagnostic performance comparable to that of MRI ECV in the detection of cardiac amyloidosis.

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