The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in <i>db</i>/<i>db</i> mice without peroxisome proliferator-activated receptor gamma–associated adverse cardiac effects
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- Rémy Hanf
- Genfit SA, Loos, France
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- Lesley J Millatt
- Genfit SA, Loos, France
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- Bertrand Cariou
- Department of Endocrinology, l’Institut du Thorax, Nantes University Hospital, Nantes, France
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- Benoit Noel
- Genfit SA, Loos, France
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- Géraldine Rigou
- Genfit SA, Loos, France
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- Philippe Delataille
- Genfit SA, Loos, France
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- Valérie Daix
- Genfit SA, Loos, France
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- Dean W Hum
- Genfit SA, Loos, France
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- Bart Staels
- Institut Pasteur de Lille, Lille, France
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説明
<jats:p> We report here the efficacy and safety of GFT505, a novel liver-targeted peroxisome proliferator-activated receptor alpha/delta (PPARα/δ) agonist, in the db/ db mouse model of diabetes. Mice were treated with vehicle, GFT505, PPARγ agonist rosiglitazone or dual-PPARα/γ agonist aleglitazar for up to 8 weeks. All compounds comparably reduced fasting glycaemia and HbA1c and improved insulin sensitivity. The glucose-lowering effect of GFT505 was associated with decreased hepatic gluconeogenesis, correlating with reduced expression of gluconeogenic genes. In contrast with the PPARγ-activating drugs, treatment with GFT505 did not affect heart weight and did not increase plasma adiponectin concentrations. This absence of cardiac effects of GFT505 was confirmed after 12 months of administration in cynomolgus monkeys, by the absence of echocardiographic and histological findings. Moreover, long-term GFT505 administration to monkeys induced no change in haematological parameters or in bone marrow differential cell counts. Compared to PPARγ-activating drugs, the dual-PPARα/δ agonist GFT505 therefore shows an improved benefit/risk ratio, treating multiple features of type 2 diabetes without inducing the cardiac side-effects associated with PPARγ activation. </jats:p>
収録刊行物
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- Diabetes and Vascular Disease Research
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Diabetes and Vascular Disease Research 11 (6), 440-447, 2014-09-11
SAGE Publications