Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality

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Description

Adeno-associated virus (AAV) vectors are promising tools for gene therapy. The current AAV vector system produces an abundance of empty capsids that are eliminated before clinical use, leading to increased costs for gene therapy. In the present study, we established an AAV production system that regulates the timing of capsid expression using a tetracycline-dependent promoter. Tetracycline-regulating capsid expression increased viral yield and reduced empty capsids in various serotypes without altering AAV vector infectivity

Journal

  • iScience

    iScience 26 (4), 106487-, 2023-04

    Elsevier BV

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