3D Printing Personalized, Photocrosslinkable Hydrogel Wound Dressings for the Treatment of Thermal Burns
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- Jia Heng Teoh
- Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Singapore
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- Anbu Mozhi
- Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Singapore
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- Vishnu Sunil
- Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Singapore
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- Sook Muay Tay
- Department of Surgical Intensive Care Division of Anesthesiology and Perioperative Medicine Singapore General Hospital Outram Road Singapore 169608 Singapore
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- Jerry Fuh
- Department of Mechanical Engineering National University of Singapore Singapore 117575 Singapore
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- Chi‐Hwa Wang
- Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Singapore
書誌事項
- 公開日
- 2021-08-27
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/adfm.202105932
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Considering the variations in burns depending on the circumstances that caused them, the need for personalized medicine and care for burn victims is vital to ensure that optimal treatment is provided. With the level of accuracy and customization that 3D printing brings as a technology, there is potential in its use to fabricate wound dressings that can provide better treatment for burn patients, provided that the material of choice has good printability and can be customized while facilitating wound healing. In this study, the versatility of chitosan methacrylate as said material to be used to fabricate customizable wound dressings via 3D printing is investigated. Synthesized chitosan methacrylate is evaluated to be printable, biodegradable, and biocompatible during wound healing. Various drugs relevant to the treatment of burns are then loaded and different multimaterial wound dressing designs containing different dosages are fabricated via 3D printing. The incorporation of said drugs does not significantly affect the printability of chitosan methacrylate, and the incorporation of antimicrobial agents significantly improves its antimicrobial capabilities. Through in vivo models, these variations in wound dressing designs have good wound healing properties and do not cause any adverse effects in the process.</jats:p>
収録刊行物
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- Advanced Functional Materials
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Advanced Functional Materials 31 (48), 2021-08-27
Wiley