Experimental pediatric stroke shows age-specific recovery of cognition and role of hippocampal Nogo-A receptor signaling

DOI Web Site Web Site 被引用文献1件
  • James E Orfila
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA
  • Robert M Dietz
    Neuronal Injury & Plasticity Program, University of Colorado School of Medicine, Aurora, CO, USA
  • Krista M Rodgers
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA
  • Andra Dingman
    Neuronal Injury & Plasticity Program, University of Colorado School of Medicine, Aurora, CO, USA
  • Olivia P Patsos
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA
  • Ivelisse Cruz-Torres
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA
  • Himmat Grewal
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA
  • Frank Strnad
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA
  • Christian Schroeder
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA
  • Paco S Herson
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA

説明

<jats:p> Ischemic stroke is a leading cause of death worldwide and clinical data suggest that children may recover from stroke better than adults; however, supporting experimental data are lacking. We used our novel mouse model of experimental juvenile ischemic stroke (MCAO) to characterize age-specific cognitive dysfunction following ischemia. Juvenile and adult mice subjected to 45-min MCAO, and extracellular field recordings of CA1 neurons were performed to assess hippocampal synaptic plasticity changes after MCAO, and contextual fear conditioning was performed to evaluate memory and biochemistry used to analyze Nogo-A expression. Juvenile mice showed impaired synaptic plasticity seven days after MCAO, followed by full recovery by 30 days. Memory behavior was consistent with synaptic impairments and recovery after juvenile MCAO. Nogo-A expression increased in ipsilateral hippocampus seven days after MCAO compared to contralateral and sham hippocampus. Further, inhibition of Nogo-A receptors reversed MCAO-induced synaptic impairment in slices obtained seven days after juvenile MCAO. Adult MCAO-induced impairment of LTP was not associated with increased Nogo-A. This study demonstrates that stroke causes functional impairment in the hippocampus and recovery of behavioral and synaptic function is more robust in the young brain. Nogo-A receptor activity may account for the impairments seen following juvenile ischemic injury. </jats:p>

収録刊行物

被引用文献 (1)*注記

もっと見る

問題の指摘

ページトップへ