Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production

  • Rafael Gil de Rubio
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.
  • Richard F. Ransom
    Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Sundeep Malik
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.
  • David I. Yule
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.
  • Arun Anantharam
    Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Alan V. Smrcka
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.

書誌事項

公開日
2018-09-11
DOI
  • 10.1126/scisignal.aan1210
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>The plasma membrane lipid PI4P is the main source of phosphoinositides generated by GPCR activation.</jats:p>

収録刊行物

  • Science Signaling

    Science Signaling 11 (547), eaan1210-, 2018-09-11

    American Association for the Advancement of Science (AAAS)

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