Design of a Continuous Tubular Cooling Crystallizer for Process Development on Lab‐Scale

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<jats:title>Abstract</jats:title><jats:p>Continuous manufacturing of fine chemical, life science, and pharmaceutical products is under recent investigation in R&D. As cooling crystallization is an important unit operation for purification of products, continuously operated, scalable devices are required for process development on lab‐scale. A tubular crystallizer was developed, based on the coiled flow inverter design. Experimental characterization proved a narrow residence time distribution of the liquid phase close to ideal plug flow. Counter‐current air cooling allows for adjusting linear and curved temperature profiles. Unseeded operation with the <jats:italic>L</jats:italic>‐alanine (water) system demonstrated that nucleation has to be actively controlled to successfully apply intensified continuous cooling crystallization processes.</jats:p>

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