Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase
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- Winda Ariyani
- Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University
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- Chiharu Yoshikawa
- Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University
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- Haruka Tsuneoka
- Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University
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- Izuki Amano
- Department of Integrative Physiology, Gunma University Graduate School of Medicine
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- Itaru Imayoshi
- Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University
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- Hiroshi Ichinose
- School of Life Science and Technology, Institute of Science Tokyo
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- Chiho Sumi-Ichinose
- Department of Pharmacology, School of Medicine, Fujita Health University
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- Noriyuki Koibuchi
- Department of Integrative Physiology, Gunma University Graduate School of Medicine
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- Tadahiro Kitamura
- Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University
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- Daisuke Kohno
- Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University
書誌事項
- 公開日
- 2025-03-28
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by-nc-nd/4.0/
- DOI
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- 10.1073/pnas.2411069122
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:p> Feeding behavior is controlled by various neural networks in the brain that are involved in different feeding phases: Food procurement, consumption, and termination. However, the specific neural circuits controlling the food consumption phase remain poorly understood. Here, we investigated the roles of dopaminergic neurons in the paraventricular nucleus of the hypothalamus (PVH) in the feeding behavior in mice. Our results indicated that the PVH dopaminergic neurons were critical for extending the food consumption phase and involved in the development of obesity through epigenetic mechanisms. These neurons synchronized with proopiomelanocortin neurons during consumption, were stimulated by proopiomelanocortin activation, and projected to the lateral habenula (LHb), where dopamine receptor D2 was involved in the increase in food consumption. In addition, upregulated tyrosine hydroxylase (TH) expression in PVH was associated with obesity and indispensable for obesity induction in mice lacking <jats:italic>Dnmt3a</jats:italic> . Taken together, our results highlight the roles of PVH dopaminergic neurons in promoting food consumption and obesity induction. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 122 (13), 2025-03-28
Proceedings of the National Academy of Sciences