Dietary intake of whale oil–containing ω‐3 long‐chain polyunsaturated fatty acids attenuates choroidal neovascularization in mice

DOI Web Site 参考文献51件 オープンアクセス
  • Ryoji Yanai
    Department of Ophthalmology, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
  • Genta Yasunaga
    Institute of Cetacean Research Chuo‐ku Tokyo Japan
  • Shunya Tsuji
    Department of Pharmacology Yamaguchi University Graduate School of Medicine Ube Yamaguchi Japan
  • Takeshi Honda
    Department of Pharmacology Yamaguchi University Graduate School of Medicine Ube Yamaguchi Japan
  • Arihiro Iwata
    Yamaguchi Prefectural Industrial Technology Institute Ube Yamaguchi Japan
  • Eiji Miyagawa
    Yamaguchi Prefectural Industrial Technology Institute Ube Yamaguchi Japan
  • Koji Yoshida
    Yoshida General Techno Co., Ltd. Shimonoseki Yamaguchi Japan
  • Mitsuhiro Kishimoto
    Faculty of Economics Shimonoseki City University Shimonoseki Yamaguchi Japan
  • Hiroki Sakai
    Institute of Cetacean Research Chuo‐ku Tokyo Japan
  • Yoshihiro Fujise
    Institute of Cetacean Research Chuo‐ku Tokyo Japan
  • Masataka Asagiri
    Department of Pharmacology Yamaguchi University Graduate School of Medicine Ube Yamaguchi Japan
  • Yoshinori Mitamura
    Department of Ophthalmology, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan

書誌事項

公開日
2025-02-12
資源種別
journal article
権利情報
  • http://creativecommons.org/licenses/by-nc-nd/4.0/
DOI
  • 10.1096/fj.202402041r
公開者
Wiley

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<jats:title>Abstract</jats:title> <jats:p>Age‐related macular degeneration (AMD) is a leading cause of blindness in Western and developing countries. Since antivascular endothelial growth factor (VEGF) therapy is available for the regression of choroidal neovascularization (CNV), it does not work for the pathophysiology of AMD so a cure is increasingly demanded. Whale oil promotes various bodily functions, such as anti‐inflammatory effects for cardiovascular disease, but its physiological mechanisms are still unclarified. Here, we examined the effects of whale oil on a mouse model of AMD. The area of CNV measured in choroidal flat‐mount preparations at 7 days after laser photocoagulation was significantly smaller in mice fed whale oil compared with control mice free of ω‐3 long‐chain polyunsaturated fatty acids (LCPUFAs). The plasma concentrations of ω‐3 LCPUFAs were higher, whereas those of ω‐6 LCPUFAs were lower in mice fed the diet containing whale oil than in those fed the control diet. The concentrations of various inflammatory cytokines and chemokines in the retina or choroid at 3 or 7 days after CNV induction differed between the two groups of mice. Furthermore, the concentration of VEGF was decreased in the retina but increased in the choroid at 7 or 3 days after photocoagulation, respectively. Our results thus show that dietary intake of whale oil–containing ω‐3 LCPUFAs attenuated CNV in association with changes in inflammatory mediator levels and VEGF expression in the retina and choroid of mice, and it, therefore, warrants further study as a means to protect against AMD in humans.</jats:p>

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