Preliminary observations on the associations between sensory processing abnormalities and event‐related potentials in adults with autism spectrum disorder

DOI Web Site 参考文献49件
  • Ryo Mizui
    Department of Psychiatry Nara Medical University School of Medicine Kashihara Japan
  • Kazuhiko Yamamuro
    Department of Psychiatry Nara Medical University School of Medicine Kashihara Japan
  • Kosuke Okazaki
    Developmental Center for Child and Adult, Shigisan Hospital Ikoma‐Gun Japan
  • Mitsuhiro Uratani
    Department of Psychiatry Nara Medical University School of Medicine Kashihara Japan
  • Natsuko Kashida
    Department of Psychiatry Nara Medical University School of Medicine Kashihara Japan
  • Rio Ishida
    Department of Psychiatry Nara Medical University School of Medicine Kashihara Japan
  • Manabu Makinodan
    Department of Psychiatry Nara Medical University School of Medicine Kashihara Japan

書誌事項

公開日
2024-02-14
資源種別
journal article
権利情報
  • http://creativecommons.org/licenses/by-nc/4.0/
DOI
  • 10.1002/pcn5.173
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is thought to involve a variety of neurophysiological characteristics. Event‐related potentials (ERPs) reflect cognitive functions in the brain's cognitive processing. In this study, we investigated differences in P300 and N100 of ERPs between ASD and typically developing groups and focused on the relationship between the components of ERPs and measures of autistic traits and sensory processing characteristics.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>ERPs were measured in 96 subjects in the ASD group and 62 subjects in the age‐ and sex‐adjusted typically developing group. Correlations between each component and the scores of the Autism‐Spectrum Quotient Japanese version (AQ‐J) and the Adolescent and Adult Sensory Profile (AASP) were also evaluated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The ASD group showed a significant decrease in the amplitude of N100 at C3. Furthermore, a negative correlation was found between lower amplitude at C3 of N100 and low registered sensory scores in both groups.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings imply that the N100 amplitude at C3 could be a potential indicator for examining the neurophysiological traits of ASD; however, these results should be interpreted with caution due to their preliminary nature. These tentative insights into sensory processing anomalies may be discernible in specific subsets of the ASD population, providing a foundation for future investigative pathways.</jats:p></jats:sec>

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